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Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations

โœ Scribed by Paola Sebastiani; Ling Wang; Vikki G. Nolan; Efthymia Melista; Qianli Ma; Clinton T. Baldwin; Martin H. Steinberg


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
243 KB
Volume
83
Category
Article
ISSN
0361-8609

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Variation in the level of fetal hemoglobin (HbF) accounts for much of the clinical heterogeneity observed in patients with sickle cell disease (SCD). The HbF level has emerged as an important prognostic factor in both sickle cell pain and mortality, and a % HbF of 10-20% has been suggested as a thre