𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Genetic disorders among Palestinian Arabs. 2. Hydrocephalus and neural tube defects

✍ Scribed by Zlotogora, Joël

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
8 KB
Volume
71
Category
Article
ISSN
0148-7299
DOI
10.1002/(sici)1096-8628(19970711)71:1<33::aid-ajmg6>3.0.co;2-r

No coin nor oath required. For personal study only.

✦ Synopsis

Congenital hydrocephalus and/or open neural tube defect was present in at least one individual of 98 families out of the 2,000 Palestinian Arabic families who have visited the Genetic clinic at the Hadassah Medical Center. In 22 families the brain malformation was part of a syndrome: Meckel syndrome in 10, Warburg syndrome in another 5, Carpenter in one, and undiagnosed in 6 families.

In 76 of the families the neural tube defect and/or the hydrocephalus were nonsyndromal. It seems that most of the cases of isolated non-syndromal hydrocephalus represented autosomal recessive traits and that an abnormal allele is common among Pales-

📜 SIMILAR VOLUMES

Aneuploidy among prenatally detected neu
Aneuploidy among prenatally detected neural tube defects
✍ Hume, Roderick F.; Drugan, Arie; Reichler, Avi; Lampinen, Jenifer; Martin, Laura 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 16 KB 👁 1 views

We have reported previously a 10% aneuploidy detection rate among 39 cases of fetal neural tube defects (NTD). Subsequently we amassed an additional experience of over 17,000 prenatal diagnosis cases over a 5-year period. During this period 106 cases of NTDs were identified; 44 with anencephaly, 62

Genetic polymorphisms in methylenetetrah
Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects
✍ Christensen, Benedicte; Arbour, Laura; Tran, Pamela; Leclerc, Daniel; Sabbaghian 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 47 KB 👁 1 views

Folic acid administration to women in the periconceptional period reduces the occurrence of neural tube defects (NTDs) in their offspring. A polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), 677C¨T, is the first genetic risk factor for NTDs in man identified at the molec

Genetic associations with clinical chara
Genetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorder
✍ Ho, Luk W.; Furlong, Robert A.; Rubinsztein, Judy S.; Walsh, Cathy; Paykel, Euge 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 30 KB 👁 1 views

Genetic factors may be associated with disease subtype as well as susceptibility. We have therefore typed polymorphisms at the serotonin transporter, dopamine receptor, tryptophan hydroxylase, tyrosine hydoxylase, and monoamine oxidase A (MAOA) loci in 139 unipolar and 131 bipolar patients and inves

Serotonin transporter (5-HTT) gene and b
Serotonin transporter (5-HTT) gene and bipolar affective disorder
✍ Esterling, Lisa E.; Yoshikawa, Takeo; Turner, Gordon; Badner, Judy A.; Bengel, D 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 15 KB 👁 1 views

Interactions with antidepressants, as well as other biochemical evidence, implicate the serotonin transporter 5-HTT in the etiology of affective disorders. However, genetic studies have produced conflicting results concerning an association of 5-HTT with bipolar disorder. We examined a variable numb