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Genetic differences in the antinociceptive effect of morphine and its potentiation by dextromethorphan in rats

✍ Scribed by Aida Plesan; Orsolya Hoffmann; Xiao-Jun Xu; Zsuzsanna Wiesenfeld-Hallin

Book ID
117477497
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
125 KB
Volume
263
Category
Article
ISSN
0304-3940

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✍ Marianne Ekblom; Marie GΓ₯rdmark; Margareta Hammarlund-Udenaes πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 555 KB

In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,