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Wheel running attenuates the antinociceptive properties of morphine and its metabolite, morphine-6-glucuronide, in rats

✍ Scribed by Wendy Foulds Mathes; Robin B Kanarek

Book ID
117197582
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
149 KB
Volume
74
Category
Article
ISSN
0031-9384

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Pharmacokinetics and pharmacodynamics of
Pharmacokinetics and pharmacodynamics of morphine-3-glucuronide in rats and its influence on the antinociceptive effect of morphine
✍ Marianne Ekblom; Marie GΓ₯rdmark; Margareta Hammarlund-Udenaes πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 555 KB

In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,