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Genetic determinants of von Willebrand factor levels and activity in relation to the risk of cardiovascular disease: a review

✍ Scribed by M. C. VAN SCHIE; J. E. VAN LOON; M. P. M. DE MAAT; F. W. G. LEEBEEK


Book ID
109154703
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
146 KB
Volume
9
Category
Article
ISSN
1538-7933

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## Abstract Decreased von Willebrand factor (VWF)‐cleaving protease activity (<5%) has been implicated in patients with congenital thrombotic thrombocytopenic purpura–hemolytic uremic syndrome (Upshaw‐Schulman syndrome) and associated with mutations within the __ADAMTS13__ gene. In this report, we