๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Genetic control of ornithine transcarbamylase induction in chick kidney

โœ Scribed by Soichi Tsuji; Kaku Nakagawa; Toyokazu Fukushima

Publisher
Springer
Year
1983
Tongue
English
Weight
639 KB
Volume
21
Category
Article
ISSN
0006-2928

No coin nor oath required. For personal study only.

โœฆ Synopsis

After ornithine transcarbamylase (OTC) induction by egg-yolk feeding, OTC activity increases rapidly in chicks bearing an Ocb gene. This response to an egg yolk diet does not appear in chicks having no Ocb gene (showing low OTC activity). The chicks showing intermediate OTC activity also respond to the diet, but moderately. Crossing experiments revealed that OTC induction by egg yolk-diet feeding is inherited as a simple autosomal dominant trait. Since a chick develops during embryonic life by utilizing egg yolk from the yolk sac, the variation of OTC activity among chicken breeds and within a breed in 2-day-old chicks seems to depend on a genetically controlled difference of inducibility by egg yolk. The Ocb is an autosomal gene which controls the induction of OTC activity, but it is difficult to explain the consistent difference in OTC activity between sexes by involving this gene or this locus alone.

๐Ÿ“œ SIMILAR VOLUMES

Genetically controlled quantitative vari
Genetically controlled quantitative variation of ornithine transcarbamylase in the chick kidney
โœ Soichi Tsuji; Kaku Nakagawa; Toyokazu Fukushima ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer ๐ŸŒ English โš– 612 KB

This experiment was made to show that the marked variation in ornithine transcarbamylase (OTC) activity observed within a chicken breed or among breeds is due to quantitative changes, not qualitative ones. The enzyme was partially purified from three different chicken breeds, the White Leghorn B lin

Autosomal genetic control of the activit
Autosomal genetic control of the activity of a new variant ornithine transcarbamylase in chicken kidney
โœ Soichi Tsuji; Toyokazu Fukushima ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› Springer ๐ŸŒ English โš– 413 KB

The mode of inheritance of the gene for chick kidney ornithine transcarbamylase (OTC), found previously as a genetic variant, was investigated. White Leghorn B line males homozygous for the allele for the variant OTC gene were selected using the California Gray breed, having a near-absolute deficien

Ahrens MJ, Berry SA, Whitley CB, Markowi
Ahrens MJ, Berry SA, Whitley CB, Markowitz DJ, Plante RJ, Tuchman M (1996): Clinical and biochemical heterogeneity in females of a large pedigree with ornithine transcarbamylase deficiency due to the R141Q mutation. Am J Med Genet 66:311-315
โœ Gilbert-Barness, Enid ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 11 KB ๐Ÿ‘ 2 views

Patients are identified by numbers corresponding to their designation on the pedigree illustration (Fig. 1).