✦ LIBER ✦

Autosomal genetic control of the activity of a new variant ornithine transcarbamylase in chicken kidney

✍ Scribed by Soichi Tsuji; Toyokazu Fukushima

Publisher: Springer
Year: 1976
Tongue: English
Weight: 413 KB
Volume: 14
Category: Article
ISSN: 0006-2928
DOI: 10.1007/bf00486130

No coin nor oath required. For personal study only.

✦ Synopsis

The mode of inheritance of the gene for chick kidney ornithine transcarbamylase (OTC), found previously as a genetic variant, was investigated. White Leghorn B line males homozygous for the allele for the variant OTC gene were selected using the California Gray breed, having a near-absolute deficiency of the enzyme. Then further crosses of the two breeds were made. The mean value of the OTC level of F1 progeny was about 170 units. Chicks from the backcross generation were divided into two groups, of high activity and low activity, in a ratio of 1:1. F2 chicks were divided into three groups: one-fourth of the chicks were classified as a "super high" group, one-half were "high," and the remaining one-fourth were "low"; the mean values for OTC level were 356.7, 196.4, and 15.6 units, respectively. From these results, it was suggested that the variant OTC represents a simple autosomal incompletely dominant trait.

📜 SIMILAR VOLUMES

Genetically controlled quantitative vari

Genetically controlled quantitative variation of ornithine transcarbamylase in the chick kidney

✍ Soichi Tsuji; Kaku Nakagawa; Toyokazu Fukushima 📂 Article 📅 1983 🏛 Springer 🌐 English ⚖ 612 KB

This experiment was made to show that the marked variation in ornithine transcarbamylase (OTC) activity observed within a chicken breed or among breeds is due to quantitative changes, not qualitative ones. The enzyme was partially purified from three different chicken breeds, the White Leghorn B lin

Autosomal genetic control of the activit

Autosomal genetic control of the activity of an esterase in rat hepatic microsomes

✍ Michael A. Zemaitis; Richard N. Hill; Frank E. Greene 📂 Article 📅 1974 🏛 Springer 🌐 English ⚖ 681 KB

Prenatal monitoring in a family at high

Prenatal monitoring in a family at high risk for ornithine transcarbamylase (OTC) deficiency: A new mutation of an A-to-C transversion in position +4 of intron 1 of the OTC gene that is likely to abolish enzyme activity

✍ Hoshide, Ryuuji; Matsuura, Toshinobu; Sagara, Yusuke; Kubo, Takahiko; Shimadzu, 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 562 KB

DNA analysis of a male propositus with ornithine transcarbamylase (OTC) deficiency documented an A-to-C substitution in position +4 of intron 1. No other abnormalities were observed in the OTC gene, or at 563 bp upstream of the 5' site, which included a promoter region, or at 383 bp downstream of th