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Genetic control of mitogen-induced B-cell hyperproliferation in SM/J mice

✍ Scribed by Roslyn Stone; David Engel

Publisher
Springer-Verlag
Year
1985
Tongue
English
Weight
374 KB
Volume
22
Category
Article
ISSN
0093-7711

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✦ Synopsis

Previous studies have shown that B cells from SM/J mice exhibit hyperproliferative responsiveness to several bacterial-derived B-cell mitogens. This hyperresponse trait was found to be under autosomal, polygenic control by non-H-2 genes. We have now estimated the number of genes involved by statistical analysis of the proliferative responses of splenocytes from SM/J and low-responder C57BL/6J strains, and progeny from the (B6 x SM)F1, F 2 and (F 1 x B6) crosses. The number of loci involved was ascertained using two different statistical approaches. An estimate of two loci was determined using chi-squared statistics. The second approach, based on an additive model in the natural log scale, also pointed to a lower bound of two genes. We conclude that the hyperresponse to B-cell mitogens in SM/J mice is determined by two autosomal genes which are not linked to the It-2 major histocompatibility complex.

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