Genetic causes of Parkinson’s disease:UCHL-1
✍ Scribed by Daniel G. Healy; Patrick M. Abou-Sleiman; Nicholas W. Wood
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 104 KB
- Volume
- 318
- Category
- Article
- ISSN
- 0302-766X
No coin nor oath required. For personal study only.
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## Abstract ## __Objective__ The __UCHL‐1__ gene is widely cited as a susceptibility factor for sporadic Parkinson's disease (PD). The strongest evidence comes from a meta‐analysis of small studies that reported the S18Y polymorphism as protective against PD, after pooling studies of white and Asi
## Abstract A recent meta‐analysis observed a greater significant inverse association of the ubiquitin carboxy‐terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) for Asian (predominantly Japanese) populations compared with Caucasian populations. We performed an independent cas