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Causes of Parkinson’s disease: genetics ofDJ-1

✍ Scribed by Patrick M. Abou-Sleiman; Daniel G. Healy; Nicholas W. Wood

Publisher: Springer-Verlag
Year: 2004
Tongue: English
Weight: 81 KB
Volume: 318
Category: Article
ISSN: 0302-766X
DOI: 10.1007/s00441-004-0922-6

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Over the last few years, several genes for monogenic forms of Parkinson's disease (PD) have been mapped and/or cloned. Mutations have been identified in the gene for alpha-synuclein in rare families with dominant PD, indicating that aggregation of this protein in Lewy bodies is probably a crucial st