Genetic association of five apolipoprotein polymorphisms with serum lipoprotein-lipid levels in African blacks

✍ Scribed by M. Ilyas Kamboh; Clareann H. Bunker; Christopher E. Aston; Cara S. Nestlerode; Andrea E. McAllister; Flora A. Ukoli

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 71 KB
• Volume: 16
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/(sici)1098-2272(1999)16:2<205::aid-gepi7>3.0.co;2-p

✦ Synopsis

Genetic studies carried out mainly in European and European-derived populations have shown that common polymorphisms in genes coding for apolipoproteins are significant determinants of serum lipoprotein-lipid levels variation. However, except for a few sporadic studies, the distribution of apolipoprotein polymorphisms and their association with serum lipoprotein-lipid levels have not been evaluated systematically in African or African-derived populations. In this investigation we have studied five apolipoprotein polymorphisms, including APOA1/MspI -75 bp, APOA1/MspI +83 bp, APOC3/PvuII, APOE, and APOH in 786 Africans (493 men, 293 women) from Nigeria. The sample is comprised of Nigerian civil servants consisting of 462 junior staff (less affluent) and 324 senior staff (more affluent) where staff status is a correlate of their socioeconomic status. We first examined genetic associations in the total sample stratified by gender to determine the role of apolipoprotein polymorphisms in affecting serum lipid profile in the general population, and then by staff status to evaluate possible gene-environment interactions. In the total sample, the APOC3/PvuII