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Genetic and expression analysis of all 7 non-synonymous single nucleotide polymorphisms in the human deoxyribonuclease II gene, with potential relevance to autoimmunity

✍ Scribed by Misuzu Ueki; Haruo Takeshita; Junko Fujihara; Kaori Kimura-Kataoka; Reiko Iida; Isao Yuasa; Tamiko Nakajima; Yoshihiko Kominato; Toshihiro Yasuda


Book ID
116348481
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
205 KB
Volume
411
Category
Article
ISSN
0009-8981

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## Abstract Members of the human DNase I family, DNase I‐like 1 and 2 (DNases 1L1 and 1L2), with physiological role(s) other than those of DNase I, possess three and one non‐synonymous SNPs in the genes, respectively. However, only limited population data are available, and the effect of these SNPs

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Global genetic analysis of all single nucleotide polymorphisms in exons of the human deoxyribonuclease I-like 3 gene and their effect on its catalytic activity Deoxyribonucleases (DNases) have been suggested to be implicated in the pathophysiology of autoimmune diseases. In the DNASE1L3 gene encodin