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A biochemical and genetic study on all non-synonymous single nucleotide polymorphisms of the gene encoding human deoxyribonuclease I potentially relevant to autoimmunity

✍ Scribed by Toshihiro Yasuda; Misuzu Ueki; Haruo Takeshita; Junko Fujihara; Kaori Kimura-Kataoka; Reiko Iida; Etsuko Tsubota; Mikiko Soejima; Yoshiro Koda; Hideaki Kato; Arturo Panduro


Book ID
116307917
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
655 KB
Volume
42
Category
Article
ISSN
1357-2725

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## Abstract Members of the human DNase I family, DNase I‐like 1 and 2 (DNases 1L1 and 1L2), with physiological role(s) other than those of DNase I, possess three and one non‐synonymous SNPs in the genes, respectively. However, only limited population data are available, and the effect of these SNPs

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Global genetic analysis of all single nucleotide polymorphisms in exons of the human deoxyribonuclease I-like 3 gene and their effect on its catalytic activity Deoxyribonucleases (DNases) have been suggested to be implicated in the pathophysiology of autoimmune diseases. In the DNASE1L3 gene encodin