This volume intends to contribute to βtranslational medicine and biologyβ. By this, we mean a bi-directional process whose aim is to develop knowledge from basic science towards diagnostic and therapeutic applications and reciprocally to raise new questions for basic scientists. One general requirem
Genetic and epigenetic changes in nasopharyngeal carcinoma
β Scribed by Kwok-Wai Lo; Dolly P Huang
- Book ID
- 114341178
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 349 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1044-579X
No coin nor oath required. For personal study only.
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## Abstract Deletion of 11q23 is a common genetic aberration in nasopharyngeal carcinoma (NPC). Multiple candidate tumor suppressor genes (TSG) were mapped to this region but few of them were investigated in NPC. __TSLC1__ (tumor suppressor in lung cancer) is recently reported to be a putative TSG
## Abstract ## Background Epigenetic silencing of tumor suppressor genes plays an important role in nasopharyngeal carcinoma (NPC) tumorigenesis. In the present study, we explore a novel target gene of epigenetic silencing in NPC, __Myocardin__, which is inactivated by promoter hypermethylation.