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Genetic and clinical analysis in 10 Spanish patients with multiple endocrine neoplasia type 1

✍ Scribed by Cebrián, Aránzazu; Herrera-Pombo, Jose Luis; Díez, Juan José; Sánchez-Vilar, Olga; Lara, Jose Ignacio; Vázquez, Clotilde; Picó, Antonio; Osorio, Ana; Martínez-Delgado, Beatriz; Benítez, Javier


Book ID
110024838
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
191 KB
Volume
7
Category
Article
ISSN
1018-4813

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## Abstract Multiple endocrine neoplasia type 2A (MEN 2A) is associated with specific germline missense mutations in the __RET__ proto‐oncogene. This locus encodes a receptor tyrosine kinase whose activation requires the formation of a multimeric receptor complex including GDNF as a ligand and GFRα