Medullary thyroid carcinoma occurs sporadically or as a part of the inherited cancer syndrome multiple endocrine neoplasia (MEN) type 2. The MEN 2 gene has been identified as the RET proto-oncogene on chromosome 10. In MEN 2A, RET mutations are detectable in one of five cysteine codons within exons
✦ LIBER ✦
Genetic analysis of seven Mediterranean families with multiple endocrine neoplasia type 2A
✍ Scribed by Josep Oriola; Cristina Hernandez; Rafael Simo; Anna Barceló; Roser Casamitjana; Enric Vilardell; Francisca Rivera-Fillat
- Book ID
- 114425200
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 360 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0300-0664
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## Abstract Multiple endocrine neoplasia type 2A (MEN 2A) is associated with specific germline missense mutations in the __RET__ proto‐oncogene. This locus encodes a receptor tyrosine kinase whose activation requires the formation of a multimeric receptor complex including GDNF as a ligand and GFRα
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