𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Genetic analysis of seven Mediterranean families with multiple endocrine neoplasia type 2A

✍ Scribed by Josep Oriola; Cristina Hernandez; Rafael Simo; Anna Barceló; Roser Casamitjana; Enric Vilardell; Francisca Rivera-Fillat


Book ID
114425200
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
360 KB
Volume
44
Category
Article
ISSN
0300-0664

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Presymptomatic genetic screening in fami
✍ A. Frilling; W. Höppner; C. Eng; L. Mulligan; F. Raue; C. E. Broelsch 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 474 KB

Medullary thyroid carcinoma occurs sporadically or as a part of the inherited cancer syndrome multiple endocrine neoplasia (MEN) type 2. The MEN 2 gene has been identified as the RET proto-oncogene on chromosome 10. In MEN 2A, RET mutations are detectable in one of five cysteine codons within exons

Genetic analysis of RET, GFRα1 and GDNF
✍ Laura Gil; Marta Azañedo; Marina Pollán; Eva Cristobal; Begoña Arribas; Luis Gar 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 112 KB 👁 1 views

## Abstract Multiple endocrine neoplasia type 2A (MEN 2A) is associated with specific germline missense mutations in the __RET__ proto‐oncogene. This locus encodes a receptor tyrosine kinase whose activation requires the formation of a multimeric receptor complex including GDNF as a ligand and GFRα