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Genetic and biochemical probes for protein—protein interactions

✍ Scribed by David S McNabb; Leonard Guarente

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
620 KB
Volume
7
Category
Article
ISSN
0958-1669

No coin nor oath required. For personal study only.

✦ Synopsis

The two-hybrid system is a powerful approach for examining protein-protein interactions. Recently, the utility of the system has been extended to include the genome-wide mapping of protein-protein interactions and the identification of peptide inhibitors of protein interactions. In addition, immunophilins and their chemical ligands are providing useful reagents for generating conditional protein-protein interactions in vivo to dissect intracellular signaling pathways.

Addresses Department of Biology 68-280, Massachusetts

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