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Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas

✍ Scribed by C.J. Kim; Y.G. Cho; J.Y. Park; T.Y. Kim; J.H. Lee; H.S. Kim; J.W. Lee; Y.H. Song; S.W. Nam; S.H. Lee; N.J. Yoo; J.Y. Lee; W.S. Park

Book ID
117660215
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
197 KB
Volume
40
Category
Article
ISSN
0959-8049

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## Communicated by Richard Wooster The human LKB gene (official HUGO symbol, STK11) encodes a serine/threonine protein kinase that is defective in patients with Peutz-Jeghers syndrome (PJS). PJS is an autosomal dominantly inherited syndrome characterized by hamartomatous polyposis of the gastroint

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The Peutz-Jeghers syndrome (PJS) is a rare hereditary disorder in which gastrointestinal hamartomatous polyposis, mucocutaneous pigmentation, and a predisposition for developing cancer are transmitted in an autosomal dominant fashion. The recently identified LKB1/STK11 gene located at chromosome 19p