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Genetic alterations in lung cancer: Assessing limitations in routine clinical use

✍ Scribed by Joana Espiga Macedo; Ângela M S Costa; Inês A M Barbosa; Sandra Rebelo; Conceição Souto de Moura; Luís Teixeira da Costa; Venceslau Hespanhol

Book ID
117805362
Publisher
Elsevier
Year
2007
Weight
826 KB
Volume
13
Category
Article
ISSN
2173-5115

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✍ Herzog, Christopher R.; Lubet, Ronald A.; You, Ming 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 123 KB 👁 2 views

Specific genetic alterations affecting known tumor suppressor genes and proto-oncogenes occur during mouse lung tumorigenesis. These include mutational activation of the K-ras gene, commonly seen at a frequency of about 80% in both spontaneously occurring and chemically induced adenomas and adenocar