๐”– Bobbio Scriptorium
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Genes that regulate apoptosis in the mouse thymus

โœ Scribed by Barbara A. Osborne; Sallie W. Smith; Kelly A. McLaughlin; Lisa Grimm; Tilmann Kallinch; Zheng-gang Liu; Lawrence M. Schwartz

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
506 KB
Volume
60
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

โœฆ Synopsis

Elimination of self-reactive T lymphocytes occurs during T-cell development in the thymus by a process known as negative selection. The mechanism that drives negative selection is apoptosis. To identify genes that regulate apoptosis in the mouse thymus, a library of negatively selected T cells was constructed and, by subtractive screening, several differentially regulated genes were isolated. Two transcripts that are repressed during cell death were identified, in addition to two induced transcripts. Further experiments demonstrated that cell death in thymocytes can occur via several induction pathways and each pathway appears to be regulated by a unique cascade of genes.

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