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Genes, environment, and the onset of Huntington's disease

✍ Scribed by Peter Hayward


Book ID
114407678
Publisher
The Lancet
Year
2004
Tongue
English
Weight
42 KB
Volume
3
Category
Article
ISSN
1474-4465

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Simulation of Huntington's disease onset
✍ Leona Enama Markson; Gary A. Chase; Ron Brookmeyer; D. C. Rao πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 582 KB

Previous investigators have noted that the type of sampling scheme used to study the natural history of Huntington's disease can affect the observed age of onset distribution. Simulated data are presented to demonstrate that bias is introduced when onset characteristics derived from prevalence sampl

Juvenile onset Huntington's disease?clin
✍ Nance, Martha A. ;Myers, Richard H. πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 124 KB

## Abstract Huntington's disease (HD) is an inherited neurodegenerative disorder. The mutation which causes the disease is an expansion in the number of repetitions of three nucleotides, C, A, and G in exon 1 of the huntingtin gene. The gene normally has 15 to 30 repeats and an expansion to 40 or m