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Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors

โœ Scribed by Okita, K.; Nakagawa, M.; Hyenjong, H.; Ichisaka, T.; Yamanaka, S.


Book ID
124057143
Publisher
American Association for the Advancement of Science
Year
2008
Tongue
English
Weight
454 KB
Volume
322
Category
Article
ISSN
0036-8075

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Induced pluripotent stem cells generated
โœ Reto Eggenschwiler; Tobias Cantz ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 132 KB ๐Ÿ‘ 1 views

Pluripotent stem cells have been generated from mouse and human somatic cells by viral expression of the transcription factors Oct4, Sox2, Klf4, and c-Myc. A major limitation of this technology is the use of potentially harmful genome-integrating viruses. Here, we generate mouse induced pluripotent