G-protein-coupled receptors (GPCRs) are integral membrane proteins involved in signal transduction and constitute major drug targets for disease therapy. Aptamers, which are globular RNA or DNA molecules evolved to specifically bind a target, could represent a valuable tool with which to probe the r
✦ LIBER ✦
Generation of mice deficient for the lymphocyte-specific G-protein-coupled receptor BLR1
✍ Scribed by A. Mattis; E. Wolf; E. Kaiser; R. Förster; M. Lipp
- Book ID
- 112784537
- Publisher
- Springer-Verlag
- Year
- 1995
- Tongue
- English
- Weight
- 143 KB
- Volume
- 121
- Category
- Article
- ISSN
- 1432-1335
No coin nor oath required. For personal study only.
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## Abstract Structural characterization of membrane proteins is hampered by their instability in detergent solutions. We modified here a G protein‐coupled receptor, the BLT1 receptor of leukotriene B~4~, to stabilize it __in vitro__. For this, we introduced a metal‐binding site connecting the third