Generation of diverse 1-imidazolylisoquinolines via silver triflate-catalyzed reaction of 2-alkynylbenzaldoxime with imidazole
โ Scribed by Xiao, Qian; Ye, Shengqing; Zheng, Danqing; Zhang, Ling; Wu, Jie
- Book ID
- 113075691
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 294 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1381-1991
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๐ SIMILAR VOLUMES
## Abstract The synthesis of the target compounds involves a AgOTfโcatalyzed 6โendo cyclization of benzaldoximes followed by PyBroPโmediated addition of phenols.
## Abstract 2โAlkynylbenzaldoximes react with carbodiimides under mild conditions and silver triflate catalysis in DMF, leading to a diverse range of 1โ(isoquinolinโ1โyl)ureas in good to excellent yields. This transformation involves tandem 6โ__endo__ cyclization, [3+2] cycloaddition, and subsequen
## Abstract Tandem 6โendo cyclization, [3+2] cycloaddition, and subsequent rearrangement are involved.