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Facile Synthesis of 1-(Isoquinolin-1-yl)ureas by Silver Triflate Catalyzed Tandem Reactions of 2-Alkynylbenzaldoximes with Carbodiimides

✍ Scribed by Shengqing Ye; Huanhuan Wang; Jie Wu

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 138 KB
Volume: 2010
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.201001040

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✦ Synopsis

Abstract

2‐Alkynylbenzaldoximes react with carbodiimides under mild conditions and silver triflate catalysis in DMF, leading to a diverse range of 1‐(isoquinolin‐1‐yl)ureas in good to excellent yields. This transformation involves tandem 6‐endo cyclization, [3+2] cycloaddition, and subsequent rearrangement.

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