Generation of Calhm1 knockout mouse and characterization of calhm1 gene expression
β Scribed by Junbing Wu, Shengyi Peng, Rong Wu, Yumin Hao, Guangju Ji, Zengqiang Yuan
- Book ID
- 113110059
- Publisher
- SP Higher Education Press
- Year
- 2012
- Tongue
- English
- Weight
- 709 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1674-800X
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A polymorphism in the calcium homeostasis modulator 1 gene (CALHM1) has recently been associated with risk of late-onset Alzheimer disease. We examined this variant (rs2986017) in 945 Caucasian Americans with late-onset Alzheimer disease and 875 age-matched Caucasian American controls. No associatio
## Abstract Previous studies showed the __Fmr1__ knockout (KO) mouse to be an excellent animal model for human fragileβX syndrome. The aim of this study was to further characterize the phenotype of these animals. Neuroanatomically, KO male mice were compared to wildβtypes (littermates) with respect