Generation of adenosine A3 receptor functionally humanized mice for the evaluation of the human antagonists
โ Scribed by Kazuya Yamano; Miho Inoue; Shigehiro Masaki; Mayumi Saki; Michio Ichimura; Mitsuo Satoh
- Book ID
- 113487802
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 639 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0006-2952
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A series of novel and known 5-substituted 7-amino-2-(2-furyl) [1,2,4]triazolo [1,5a][1,3,5]triazine derivatives were synthesized and tested for adenosine receptor antagonism in radioligand binding assays at all four adenosine receptor subtypes and for inhibition of the agonist-induced cyclic AMP res
Partial agonists and antagonists were synthesized and evaluated biologically for extended pharmacologic characterization of the human adenosine A 3 receptor. The affinities of all compounds were determined at the human adenosine A 3 receptor stably transfected in HEK 293 cells and in rat brain membr