✦ LIBER ✦

Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer

✍ Scribed by Mariola Kulawiec; Jesse J. Salk; Nolan G. Ericson; Jonathan Wanagat; Jason H. Bielas

Book ID: 102833237
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 653 KB
Volume: 51
Category: Article
ISSN: 0893-6692
DOI: 10.1002/em.20582

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Exciting new studies are increasingly strengthening the link between mitochondrial mutagenesis and tumor progression. Here we provide a comprehensive review and meta‐analysis of studies reporting on mitochondrial DNA mutations in common human cancers. We discuss possible mechanisms by which mitochondrial DNA mutations may influence carcinogenesis, outline important caveats for interpreting the detected mutations—particularly differentiating causality from association–and suggest how new mutational assays may help resolve fundamental controversies in the field and delineate the origin and expansion of neoplastic cell lineages. Finally, we discuss the potential clinical utility of mtDNA mutations for improving the sensitivity of early cancer diagnosis, rapidly detecting cancer recurrence, and predicting the disease outcome. Environ. Mol. Mutagen., 2010. © 2010 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Mitochondrial DNA mutations in head and

Mitochondrial DNA mutations in head and neck cancer are infrequent and lack prognostic utility

✍ Challen, C; Brown, H; Cai, C; Betts, G; Paterson, I; Sloan, P; West, C; Birch-Ma 📂 Article 📅 2011 🏛 Nature Publishing Group 🌐 English ⚖ 381 KB

Somatic mutations of mitochondrial DNA i

Somatic mutations of mitochondrial DNA in digestive tract cancers

✍ KAZUHIRO KOSE; TORU HIYAMA; SHINJI TANAKA; MASAHARU YOSHIHARA; WATARU YASUI; KAZ 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB

Somatic mutations of mitochondrial genom

Somatic mutations of mitochondrial genome in early stage breast cancer

✍ Cheng-Ye Wang; Hua-Wei Wang; Yong-Gang Yao; Qing-Peng Kong; Ya-Ping Zhang 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 212 KB 👁 1 views

## Abstract The complete mitochondrial genomes of the primary cancerous, matched paracancerous normal and distant normal tissues from 10 early‐stage breast cancer patients were analyzed in this study, with special attempt (__i__) to investigate whether the reported high frequency of mitochondrial D

Analysis of mitochondrial DNA somatic mu

Analysis of mitochondrial DNA somatic mutations in OXYS and Wistar strain rats

✍ U. N. Rotskaya; I. B. Rogozin; E. A. Vasyunina; N. G. Kolosova; B. A. Malyarchuk 📂 Article 📅 2009 🏛 Springer 🌐 English ⚖ 239 KB

Frequent somatic mutations of mitochondr

Frequent somatic mutations of mitochondrial DNA in esophageal squamous cell carcinoma

✍ Hiroshi Kumimoto; Yoshihiro Yamane; Yoshio Nishimoto; Hiroko Fukami; Masayuki Sh 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 70 KB

## Abstract Recent studies of various cancers, such as those of the breast, head and neck, bladder and lung, reported that 46–64% of somatic mutations in the D‐loop region of mitochondrial DNA (mtDNA) are observed. However, in esophageal cancer, only a low rate (5%) of somatic mutations has so far

Novel heteroplasmic frameshift and misse

Novel heteroplasmic frameshift and missense somatic mitochondrial DNA mutations in oral cancer of betel quid chewers

✍ Duan-Jun Tan; Julia Chang; Woan-Ling Chen; Lesley J. Agress; Kun-Tu Yeh; Baotyan 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 1009 KB

## Abstract Mitochondrial DNA (mtDNA) has been proposed to be involved in carcinogenesis because of its high susceptibility to oxidative DNA damage and limited repair mechanisms. For investigation of the potential role of somatic mtDNA mutations in the tumorigenesis of oral cancer, we screened the