Generation and interpretation of protein sequence and structural multiple alignments
โ Scribed by Geoffrey J. Barton; Robert B. Russell; Craig D. Livingstone
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 115 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1573-4943
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๐ SIMILAR VOLUMES
An easy and uncomplicated method to predict the solvent accessibility state of a site in a multiple protein sequence alignment is described. The approach is based on amino acid exchange and compositional preference matrices for each of three accessibility states: buried, exposed, and intermediate. C
Sequence alignment programs such as BLAST and PSI-BLAST are used routinely in pairwise, profile-based, or intermediate-sequencesearch (ISS) methods to detect remote homologies for the purposes of fold assignment and comparative modeling. Yet, the sequence alignment quality of these methods at low se