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Generating improved single-chain Fv molecules for tumor targeting

โœ Scribed by Gregory P Adams; Robert Schier

Book ID
114052276
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
209 KB
Volume
231
Category
Article
ISSN
0022-1759

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The MDR1 gene product P-glycoprotein (Pgp) plays a key role in multidrug resistance of cancer cells. Pgp is an ATPdriven efflux pump that extrudes a variety of dissimilar hydrophobic cytotoxic compounds. P-glycoprotein overexpression results in multidrug resistance (MDR) of tumor cell lines in vitro