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Generalized analysis of quantal dose-response curves

โœ Scribed by Rudolph H. de Jong


Publisher
Elsevier Science
Year
1973
Tongue
English
Weight
451 KB
Volume
6
Category
Article
ISSN
0010-4809

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โœฆ Synopsis


Statistical advances now have broadened the scope of quanta1 dose-response analysis. Currently used probit and logit techniques suffer from two drawbacks, of which their inability to handle 0 % and 100 % responses is particularly troublesome. As a consequence, observations must be bunched into dose groups.

The present method generalizes quanta1 dose analysis by treating observations as individual yes-or-no events. Grouping thus is no longer essential. Further advantages are that the dose-response curve is defined in terms of the salient parameter, the EDscr (median dose), so yielding its magnitude and variance directly.


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