Generalized analysis of quantal dose-response curves
โ Scribed by Rudolph H. de Jong
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- English
- Weight
- 451 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0010-4809
No coin nor oath required. For personal study only.
โฆ Synopsis
Statistical advances now have broadened the scope of quanta1 dose-response analysis. Currently used probit and logit techniques suffer from two drawbacks, of which their inability to handle 0 % and 100 % responses is particularly troublesome. As a consequence, observations must be bunched into dose groups.
The present method generalizes quanta1 dose analysis by treating observations as individual yes-or-no events. Grouping thus is no longer essential. Further advantages are that the dose-response curve is defined in terms of the salient parameter, the EDscr (median dose), so yielding its magnitude and variance directly.
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