General synthetic route to hexaamine macrocycles
✍ Scribed by Martin, Andrea E.; Bulkowski, John E.
- Book ID
- 120236721
- Publisher
- American Chemical Society
- Year
- 1982
- Tongue
- English
- Weight
- 572 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
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## Abstract Benzylic zinc reagents add with high regioselectivity to 1‐(phenoxycarbonyl) salts derived from pyridine‐3‐carboxaldehyde (1a) or 3‐acetylpyridine (1b) to yield 1‐(phenoxylcarbonyl)‐4‐benzyl‐1,4‐dihydropyridine‐3‐carboxaldehydes 5a, 5c or ketones 5b, 5d. Aromatizations of these dihydro
## Abstract A new synthetic route to 4‐substituted‐2,2′‐bithiophenes has been developed utilizing 4‐bromo‐2,2′‐bithiophene (1). Formation of the bithienyllithium adduct __via__ halogen‐metal exchange was found to be problematic and resulted in complex mixtures of products. The Grignard reagent of 1