General Synthesis of optically active 4-alkyl (or alkenyl)-γ-lactones from glutamic acid enantiomers

Conjugate addition to chiral γ-heterosub

Conjugate addition to chiral γ-heterosubstituted δ-lactones as pivotal synthons from L-glutamic acid. Synthesis of an optically active lignan lactone; (−)-hinokinin

✍ Hidemi Yoda; Satoshi Naito; Kunihiko Takabe; Nobuo Tanaka; Ken Hosoya 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 238 KB

Asymmetric induction in conjugate addition of new chiral Yheterosubstituted-a,~-unsaturated 6-lactones from L-glutamic acid was accomplished in high diastereoselectivity with the formation of trans-(R,S)-adducts and was disclosed to serve as a versatile procedure for the asymmetric synthesis of anti