✦ LIBER ✦

Conjugate addition to chiral γ-heterosubstituted δ-lactones as pivotal synthons from L-glutamic acid. Synthesis of an optically active lignan lactone; (−)-hinokinin

✍ Scribed by Hidemi Yoda; Satoshi Naito; Kunihiko Takabe; Nobuo Tanaka; Ken Hosoya

Publisher: Elsevier Science
Year: 1990
Tongue: French
Weight: 238 KB
Volume: 31
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)97315-5

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✦ Synopsis

Asymmetric induction in conjugate addition of new chiral Yheterosubstituted-a,~-unsaturated 6-lactones from L-glutamic acid was accomplished in high diastereoselectivity with the formation of trans-(R,S)-adducts and was disclosed to serve as a versatile procedure for the asymmetric synthesis of antileukemic lignan lactones.