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General routes for the synthesis of mono, di and tri-N-substituted derivatives of cyclam

✍ Scribed by I.M. Helps; D. Parker; J.R. Morphy; J. Chapman


Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
622 KB
Volume
45
Category
Article
ISSN
0040-4020

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## Abstract The synthesis of the crystalline and easily accessible phosphorylating agent 4‐nitrophenyl 4‐morpholinylphosphonochloridate is reported. Its application to the preparation of 5′‐phosphorylated ribonucleosides (__e.g.__ pA, ppA and pppA) as well as RNA fragments (__e.g.__ pUpU and ppUpU)