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Gene–gene interaction between MAOA and COMT in suicidal behavior: Analysis in schizophrenia

✍ Scribed by Vincenzo De Luca; Subi Tharmalingam; Daniel J. Müller; Greg Wong; Andrea de Bartolomeis; James L. Kennedy

Book ID: 113501729
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 118 KB
Volume: 1097
Category: Article
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2006.04.053

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## Abstract Several lines of evidence suggest that psychosis is associated with altered dopaminergic neurotransmission. Dopamine is catabolized by monoamine oxidase (MAO) and catechol‐O‐methyl transferase (COMT). We hypothesized that the genes encoding MAOA and COMT might contain genetic variation