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Gene therapy in the CNS

✍ Scribed by Costantini, L C; Bakowska, J C; Breakefield, X O; Isacson, O


Book ID
110038618
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
272 KB
Volume
7
Category
Article
ISSN
0969-7128

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## Abstract ## Background Brain‐directed prenatal gene therapy may benefit some lysosomal storage diseases that affect the central nervous system (CNS) before birth. Our previous study showed that intrauterine introduction of recombinant adenoviruses into cerebral ventricles results in efficient g

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Olig gene function in CNS development an
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## Abstract __Olig1__ and __Olig2__ encode basic helix‐loop‐helix (bHLH) transcription factors that are expressed in both the developing and mature vertebrate central nervous system. While numerous studies have established critical functions for __Olig__ genes during the formation of motor neurons