Advances in gene targeting methods
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Ralf KΓΌhn; Frieder Schwenk
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Article
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1997
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Elsevier Science
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English
β 554 KB
Gene targeting in embryonic stem cells is commonly used for gene inactivation and the generation of mouse mutants. The combined use of methods for site-specific and homologous DNA recombination expands the potential of gene targeting in embryonic stem cells considerably and offers the opportunity of