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Gene targeting in the rat: advances and opportunities

✍ Scribed by Howard J. Jacob; Jozef Lazar; Melinda R. Dwinell; Carol Moreno; Aron M. Geurts


Book ID
113933135
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
497 KB
Volume
26
Category
Article
ISSN
0168-9525

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Gene targeting in embryonic stem cells is commonly used for gene inactivation and the generation of mouse mutants. The combined use of methods for site-specific and homologous DNA recombination expands the potential of gene targeting in embryonic stem cells considerably and offers the opportunity of