✦ LIBER ✦

Advances in gene targeting methods

✍ Scribed by Ralf Kühn; Frieder Schwenk

Book ID: 104358753
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 554 KB
Volume: 9
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(97)80133-1

No coin nor oath required. For personal study only.

✦ Synopsis

Gene targeting in embryonic stem cells is commonly used for gene inactivation and the generation of mouse mutants. The combined use of methods for site-specific and homologous DNA recombination expands the potential of gene targeting in embryonic stem cells considerably and offers the opportunity of conditional gene targeting in mice.

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