With rapid advances in genotyping technologies in recent years and the growing number of available markers, genomewide association studies are emerging as promising approaches for the study of complex diseases and traits. However, there are several challenges with analysis and interpretation of such
Gene set analysis of genome-wide association studies: Methodological issues and perspectives
β Scribed by Lily Wang; Peilin Jia; Russell D. Wolfinger; Xi Chen; Zhongming Zhao
- Book ID
- 116981992
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 432 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0888-7543
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## Abstract Genomeβwide association studies have recently identified many new loci associated with human complex diseases. These newly discovered variants typically have weak effects requiring studies with large numbers of individuals to achieve the statistical power necessary to identify them. Lik
Despite the success of genome-wide association studies, much of the genetic contribution to complex human traits is still unexplained. One potential source of genetic variation that may contribute to this βmissing heritabilityβ is that which differs in magnitude and/or direction between males and fe