With rapid advances in genotyping technologies in recent years and the growing number of available markers, genomewide association studies are emerging as promising approaches for the study of complex diseases and traits. However, there are several challenges with analysis and interpretation of such
Gene and pathway-based second-wave analysis of genome-wide association studies
β Scribed by Peng, Gang; Luo, Li; Siu, Hoicheong; Zhu, Yun; Hu, Pengfei; Hong, Shengjun; Zhao, Jinying; Zhou, Xiaodong; Reveille, John D; Jin, Li
- Book ID
- 109848973
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 202 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1018-4813
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## Abstract Many complex diseases are influenced by genetic variations in multiple genes, each with only a small marginal effect on disease susceptibility. Pathway analysis, which identifies biological pathways associated with disease outcome, has become increasingly popular for genomeβwide associa
## Abstract Genomeβwide association studies have recently identified many new loci associated with human complex diseases. These newly discovered variants typically have weak effects requiring studies with large numbers of individuals to achieve the statistical power necessary to identify them. Lik