It is widely accepted that pathogenesis of childhood acute lymphoblastic leukemia (ALL) is related to the interplay between specific environmental exposure and inherited background. Major role of some members of the ATP-binding cassette (ABC) family of membrane transporters including MDR1 (ABCB1, P-
โฆ LIBER โฆ
Gene polymorphisms of ABC transporters are associated with clinical outcomes in children with acute lymphoblastic leukemia
โ Scribed by Zhai, Xiaowen; Wang, Hongsheng; Zhu, Xiaohua; Miao, Hui; Qian, Xiaowen; Li, Jun; Gao, Yijin; Lu, Fengjuan; Wu, Yue
- Book ID
- 118744910
- Publisher
- Termedia Publishing House
- Year
- 2012
- Tongue
- English
- Weight
- 161 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1734-1922
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The aim of this study is to determine whether the polymorphisms of the MDR1 gene are associated with the development of childhood acute lymphoblastic leukemia (ALL). The MDR1 gene polymorphisms, -2352 G>A, -934A>G, -692T>C (5' regulatory region) and 3435C>T (exon 26), were examined in 157 ALL patien