✦ LIBER ✦

Do polymorphisms in ABC transporter genes influence risk of childhood acute lymphoblastic leukemia?

✍ Scribed by Krzysztof Jamroziak; Tadeusz Robak

Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 79 KB
Volume: 32
Category: Article
ISSN: 0145-2126
DOI: 10.1016/j.leukres.2008.01.009

No coin nor oath required. For personal study only.

✦ Synopsis

It is widely accepted that pathogenesis of childhood acute lymphoblastic leukemia (ALL) is related to the interplay between specific environmental exposure and inherited background. Major role of some members of the ATP-binding cassette (ABC) family of membrane transporters including MDR1 (ABCB1, P-glycoprotein) and breast cancer resistant protein (BCRP, ABCG2) is protection against environmental toxins. Here, we review several recent reports on potential association between single nucleotide polymorphisms (SNPs) in genes encoding for ABC transporters with predisposition to pediatric ALL.

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