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Gene fusions by chromothripsis of chromosome 5q in the VCaP prostate cancer cell line

✍ Scribed by Inês Teles Alves, Saskia Hiltemann, Thomas Hartjes, Peter van der Spek…

Book ID: 120909227
Publisher: Springer
Year: 2013
Tongue: English
Weight: 425 KB
Volume: 132
Category: Article
ISSN: 0340-6717
DOI: 10.1007/s00439-013-1308-1

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## Abstract Previously we immortalized human, nontransformed prostate epithelial cells with SV40 large T‐antigen (SV40TAg) and derived increasingly aggressive sublines from the immortalized line. The progression of the tumorigenic sublines to metastatic capacity was accompanied by the formation of