Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome
✍ Scribed by Kyng, Kasper J; May, Alfred; Stevnsner, Tinna; Becker, Kevin G; Kølvrå, Steen; Bohr, Vilhelm A
- Book ID
- 110069739
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 502 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0950-9232
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Transcriptional activation of c-fos in response to both serum stimulation and D N A damage requires the serum response element. The inability of in vitro aged or senescent fibroblasts to proliferate in response to serum has been shown to be associated with repressed c-fos expression and reduced AP-1
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