We have established a gene regulatory system in mice by the inducible anti-sense RNA. We have generated transgenic mice carrying the anti-sense DNA composed of the class II MHC gene under the control of the human metallothionein IIa gene promoter. The detectable amount of anti-sense RNA was constitu
β¦ LIBER β¦
Gene expression: Regulation by anti-sense RNA
β Scribed by Travers, Andrew
- Book ID
- 109736762
- Publisher
- Nature Publishing Group
- Year
- 1984
- Tongue
- English
- Weight
- 137 KB
- Volume
- 311
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/311410a0
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## Abstract Recent evidence suggests that gene expression may be regulated, at least in part, at postβtranscriptional level by factors inducing the extremely rapid degradation of messenger RNAs. These factors include reactions between adenylβuridylβrich elements (AREs) of the relevant mRNA and eith