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Gene expression profiling of colorectal cancer cell lines exposed to 5-fluorouracil (5-FU) and 5-FdUrd

Book ID
117659393
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
267 KB
Volume
38
Category
Article
ISSN
0959-8049

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## Abstract Loss of DNA mismatch repair (MMR) occurs in 10–15% of sporadic colorectal cancer, is usually caused by hMLH1 hypermethylation, and has been shown to confer resistance to various chemotherapeutic reagents, including 5‐fluorouracil (5‐FU). We tested the hypothesis that demethylation of th