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Gene Expression Profiles in a Transgenic Animal Model of Fragile X Syndrome

✍ Scribed by Velia D'Agata; Stephen T. Warren; Weiqin Zhao; Enrique R. Torre; Daniel L. Alkon; Sebastiano Cavallaro


Book ID
115641724
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
257 KB
Volume
10
Category
Article
ISSN
0969-9961

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The fragile X mental retardation 1 gene (FMR1) mutation is strongly correlated with specific and marked neurobehavioral and neuroanatomical abnormalities. The protein product, FMRP, is highly expressed in neurons of the normal mammalian brain, and absent or in low levels in leukocytes from individua