In vitro human skin fibroblasts aging was characterized by a continuous increase of collagenase mRNA levels. On the contrary, TIMPβ1 mRNA level decreased only at late passages (> 65% of proliferative life span). Type I and III mRNA levels showed a high variability depending on cell strains studied.
Gene expression of types I and III collagen, decorin, matrix metalloproteinases and tissue inhibitors of metalloproteinases in skin fibroblasts from patients with systemic sclerosis
β Scribed by K. Kuroda; H. Shinkai
- Publisher
- Springer-Verlag
- Year
- 1997
- Tongue
- English
- Weight
- 165 KB
- Volume
- 289
- Category
- Article
- ISSN
- 0340-3696
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