Gene expression of transforming growth factor β receptors I and II in non-small-cell lung tumors
✍ Scribed by Antonella Colasante; Francesca B Aiello; Mauro Brunetti; Francesco S di Giovine
- Book ID
- 116397355
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 345 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1043-4666
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In mammals, transforming growth factor-beta (TGF-beta) is found in 3 highly homologous isoforms that exert their effects via heteromeric complexes of type-I and type-II receptors (TbetaR-I and TbetaR-II). TGF-beta regulates the growth and metabolism of various cell types, including keratinocytes. We
To elucidate the role of transforming growth factor-beta1 (TGF-beta1) and the TGF-beta type II receptor (TGF-beta RII) as tumor-suppressor genes in lung carcinogenesis, we mated C57BL/6 mice heterozygous (HT) for deletion of the TGF-beta1 gene with A/J mice to produce AJBL6 TGF-beta1 HT progeny and